CJ Lab
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Ougan (Citrus reticulata cv. Suavissima) flavedo extract suppresses cancer motility by interfering with epithelial-to-mesenchymal transition in SKOV3 cells
Bortezomib sensitizes human osteosarcoma cells to adriamycin-induced apoptosis through ROS-dependent activation of p-eIF2α/ATF4/CHOP axis.
Aldo-Keto Reductase AKR1C1-AKR1C4: Functions, Regulation, and Intervention for Anti-cancer Therapy
AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer.
SIRT7 Is an RNA-Activated Protein Lysine Deacylase.
S-Palmitoylation of Junctional Adhesion Molecule C Regulates Its Tight Junction Localization and Cell Migration.
Comparative Nucleotide-Dependent Interactome Analysis Reveals Shared and Differential Properties of KRas4a and KRas4b
Direct Comparison of SIRT2 Inhibitors: Potency, Specificity, Activity-Dependent Inhibition, and On-Target Anticancer Activities.
A Small-Molecule SIRT2 Inhibitor That Promotes K-Ras4a Lysine Fatty-Acylation
2-Bromopalmitate sensitizes osteosarcoma cells to adriamycin-induced apoptosis via the modulation of CHOP
CT-707 targets intratumor hypoxia of liver cancer by interrupting hypoxia-activated IGF-1R-YAP axis.
Ubiquitin-dependent Degradation of CDK2 Drives the Therapeutic Differentiation of AML by Targeting PRDX2.
Activity-Guided Design of HDAC11-Specific Inhibitors.
Protein phase separation: A novel therapy for cancer?
The role of autophagy in targeted therapy for acute myeloid leukemia.
Suppression of hypoxia-inducible factor 1α (HIF-1α) by tirapazamine is dependent on eIF2α phosphorylation rather than the mTORC1/4E-BP1 pathway
Tumor hypoxia enhances Non-Small Cell Lung Cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling.
Novel Lysine-Based Thioureas as Mechanism-Based Inhibitors of Sirtuin 2 (SIRT2) with Anticancer Activity in a Colorectal Cancer Murine Model.
YQ36: a novel bisindolylmaleimide analogue induces KB/VCR cell death.
Cap-dependent translation initiation factor, eIF4E, is the target for Ouabain-mediated inhibition of HIF-1α.
The oxidation states of DJ-1 dictate the cell fate in response to oxidative stress triggered by 4-HPR: autophagy or apoptosis.
DJ-1 as a human oncogene and potential therapeutic target.
DNA-PKcs, a novel functional target of acriflavine, mediates acriflavine's p53-dependent synergistic anti-tumor efficiency with melphalan
Novel potent HIF-1 inhibitors for the prevention of tumor metastasis: discovery and optimization of 3-aryl-5-indazole-1,2,4-oxadiazole derivatives
The involvement of M2 macrophage polarization inhibition in fenretinide-mediated chemopreventive effects on colon cancer.
The Role of Ferroptosis in Cancer Development and Treatment Response.
Cellular Senescence and Anti-Cancer Therapy
Immune cells in the tumour: new routes of retinoids for chemoprevention and chemotherapeutics
Identification of PRDX6 as a regulator of ferroptosis
Stress granule: a promising target for cancer treatment.
Neohesperidin Prevents Colorectal Tumorigenesis by Altering the Gut Microbiota.
Small molecule inhibitors targeting the PD-1/PD-L1 signaling pathway
N-myristoylation: from cell biology to translational medicine.
The C terminus of DJ-1 determines its homodimerization, MGO detoxification activity and suppression of ferroptosis.
Bis-isatin derivatives: design, synthesis, and biological activity evaluation as potent dimeric DJ-1 inhibitors
Beyond iron deposition: making sense of the latest evidence on ferroptosis in Parkinson's disease
Discovery of 5,6-Bis(4-methoxy-3-methylphenyl)pyridin-2-amine as a WSB1 Degrader to Inhibit Cancer Cell Metastasis.
Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy
One therapeutic approach for triple-negative breast cancer: Checkpoint kinase 1 inhibitor AZD7762 combination with neoadjuvant carboplatin
PD-1/PD-L1 counterattack alliance: multiple strategies for treating triple-negative breast cancer.
Targeting Myc Interacting Proteins as a Winding Path in Cancer Therapy.
TGSA: Protein-Protein Association-Based Twin Graph Neural Networks for Drug Response Prediction with Similarity Augmentation
Tumor immunity: a novel dimension for PROTACs to conquer cancer?
Progress and perspective of organoid technology in cancer-related translational medicine.
ZDHHC12-mediated claudin-3 S-palmitoylation determines ovarian cancer progression
LncRNA-MM2P Identified as a Modulator of Macrophage M2 Polarization
Hypoxia-Induced WSB1 Promotes the Metastatic Potential of Osteosarcoma Cells.
HDAC11 regulates type I interferon signaling through defatty-acylation of SHMT2
WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit.
DJ-1 suppresses ferroptosis through preserving the activity of S-adenosyl homocysteine hydrolase
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